Publications
1. Zilberter, Y. I., Timin, E. N., Bendukidze, Z. A. & Burnashev, N. A. Micropipet method of recording fast inward currents of single heart-muscle cells. Bull. Exp. Biol. Med. 92, 17510–11753 (1981).
2. Zilberter, Y. I., Timin, E. N., Bendukidze, Z. A. & Burnashev, N. A. Patch-voltage-clamp method for measuring fast inward current in single rat heart muscle cells. Pflugers Arch. 394, 150–155 (1982).
3. Burnashev, N. A. & Zilberter Yu, I. Two types of single inward rectifying potassium channels in rat myocardial cells. Gen. Physiol. Biophys. 5, 495–504 (1986).
4. Zilberter, Y., Burnashev, N., Papin, A., Portnov, V. & Khodorov, B. Gating kinetics of ATP-sensitive single potassium channels in myocardial cells depends on electromotive force. Pflugers Arch. 411, 584–589 (1988).
5. Zilberter, Y. I., Uteshev, V. V., Sokolova, S. N., Motin, L. G. & Eremjan, H. H. Potentiation of glutamate-activated currents in isolated hippocampal neurons. Neuron 5, 597–602 (1990).
6. Zilberter, Y., Motin, L., Sokolova, S., Papin, A. & Khodorov, B. Ca-sensitive slow inactivation and lidocaine-induced block of sodium channels in rat cardiac cells. J. Mol. Cell. Cardiol. 23 Suppl 1, 61–72 (1991).
7. Zilberter, Y., Uteshev, V., Sokolova, S. & Khodorov, B. Desensitization of N-methyl-D-aspartate receptors in neurons dissociated from adult rat hippocampus. Mol. Pharmacol. 40, 337–341 (1991).
8. Zilberter, Y. I. & Motin, L. G. Existence of two fast inactivation states in cardiac Na channels confirmed by two-stage action of proteolytic enzymes. Biochim. Biophys. Acta 1068, 77–80 (1991).
9. Grant, A. O., Wendt, D. J., Zilberter, Y. & Starmer, C. F. Kinetics of interaction of disopyramide with the cardiac sodium channel: fast dissociation from open channels at normal rest potentials. J. Membr. Biol. 136, 199–214 (1993).
10. Zilberter, Y. I., Starmer, C. F. & Grant, A. O. Open Na+ channel blockade: multiple rest states revealed by channel interactions with disopyramide and quinidine. Am. J. Physiol. 266, H2007–17 (1994).
11. Zilberter Yu, I., Starmer, C. F., Starobin, J. & Grant, A. O. Late Na channels in cardiac cells: the physiological role of background Na channels. Biophys. J. 67, 153–160 (1994).
12. Starmer, C. F., Romashko, D. N., Reddy, R. S., Zilberter, Y. I., Starobin, J., Grant, A. O. & Krinsky, V. I. Proarrhythmic response to potassium channel blockade. Numerical studies of polymorphic tachyarrhythmias. Circulation 92, 595–605 (1995).
13. Starobin, J. M., Zilberter, Y. I., Rusnak, E. M. & Starmer, C. F. Wavelet formation in excitable cardiac tissue: the role of wavefront-obstacle interactions in initiating high-frequency fibrillatory-like arrhythmias. Biophys. J. 70, 581–594 (1996).
14. Rozov, A., Zilberter, Y., Wollmuth, L. P. & Burnashev, N. Facilitation of currents through rat Ca2+-permeable AMPA receptor channels by activity-dependent relief from polyamine block. J. Physiol. 511 ( Pt 2), 361–377 (1998).
15. Zilberter, Y., Kaiser, K. M. & Sakmann, B. Dendritic GABA release depresses excitatory transmission between layer 2/3 pyramidal and bitufted neurons in rat neocortex. Neuron 24, 979–988 (1999).
16. Zilberter, Y. Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex. J. Physiol. 528, 489–496 (2000).
17. Holmgren, C. D. & Zilberter, Y. Coincident spiking activity induces long-term changes in inhibition of neocortical pyramidal cells. J. Neurosci. 21, 8270–8277 (2001).
18. Kaiser, K. M., Zilberter, Y. & Sakmann, B. Back-propagating action potentials mediate calcium signalling in dendrites of bitufted interneurons in layer 2/3 of rat somatosensory cortex. J. Physiol. 535, 17–31 (2001).
19. Zilberter, Y. Short-term retrograde signaling in brain synapses. Biol. Membrany 19, 90–92 (2002).
20. Harkany, T., Hartig, W., Berghuis, P., Dobszay, M. B., Zilberter, Y., Edwards, R. H., Mackie, K. & Ernfors, P. Complementary distribution of type 1 cannabinoid receptors and vesicular glutamate transporter 3 in basal forebrain suggests input-specific retrograde signalling by cholinergic neurons. Eur. J. Neurosci. 18, 1979–1992 (2003).
21. Holmgren, C., Harkany, T., Svennenfors, B. & Zilberter, Y. Pyramidal cell communication within local networks in layer 2/3 of rat neocortex. J. Physiol. 551, 139–153 (2003).
22. Eriksson, D., Fransen, E., Zilberter, Y. & Lansner, A. Effects of short-term synaptic plasticity in a local microcircuit on cell. Neurocomputing 52-4, 7–12 (2003).
23. Lucas, G., Hendolin, P., Harkany, T., Agerman, K., Paratcha, G., Holmgren, C., Zilberter, Y., Sairanen, M., Minichiello, L., Castren, E. & Ernfors, P. Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia. Nat. Neurosci. 6, 221–222 (2003).
24. Berghuis, P., Dobszay, M. B., Sousa, K. M., Schulte, G., Mager, P. P., Hartig, W., Gorcs, T. J., Zilberter, Y., Ernfors, P. & Harkany, T. Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons. Eur. J. Neurosci. 20, 1290–1306 (2004).
25. Harkany, T., Andang, M., Kingma, H. J., Gorcs, T. J., Holmgren, C. D., Zilberter, Y. & Ernfors, P. Region-specific generation of functional neurons from naive embryonic stem cells in adult brain. J. Neurochem. 88, 1229–1239 (2004).
26. Harkany, T., Holmgren, C., Hartig, W., Qureshi, T., Chaudhry, F. A., Storm-Mathisen, J., Dobszay, M. B., Berghuis, P., Schulte, G., Sousa, K. M., Fremeau, R. T., Jr., Edwards, R. H., Mackie, K., Ernfors, P. & Zilberter, Y. Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3. J. Neurosci. 24, 4978–4988 (2004).
27. Kaiser, K. M., Lubke, J., Zilberter, Y. & Sakmann, B. Postsynaptic calcium influx at single synaptic contacts between pyramidal neurons and bitufted interneurons in layer 2/3 of rat neocortex is enhanced by backpropagating action potentials. J. Neurosci. 24, 1319–1329 (2004).
28. Korngreen, A., Kaiser, K. M. & Zilberter, Y. Subthreshold inactivation of voltage-gated K+ channels modulates action potentials in neocortical bitufted interneurones from rats. J. Physiol. 562, 421–437 (2005).
29. Zilberter, Y., Harkany, T. & Holmgren, C. D. Dendritic release of retrograde messengers controls synaptic transmission in local neocortical networks. Neuroscientist 11, 334–344 (2005).
30. Shemer, I., Holmgren, C., Min, R., Fulop, L., Zilberter, M., Sousa, K. M., Farkas, T., Hartig, W., Penke, B., Burnashev, N., Tanila, H., Zilberter, Y. & Harkany, T. Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. Eur. J. Neurosci. 23, 2035–2047 (2006).
31. Ivanov, A., Tyzio, R., Zilberter, Y. & Ben-Ari, Y. (R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus. Neuroscience 156, 277–288 (2008).
32. Rheims, S., Minlebaev, M., Ivanov, A., Represa, A., Khazipov, R., Holmes, G. L., Ben-Ari, Y. & Zilberter, Y. Excitatory GABA in Rodent Developing Neocortex In Vitro. J. Neurophysiol. 100, 609–619 (2008).
33. Rheims, S., Represa, A., Ben-Ari, Y. & Zilberter, Y. Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses. J. Neurophysiol. 100, 620–628 (2008).
34. Tyzio, R., Minlebaev, M., Rheims, S., Ivanov, A., Jorquera, I., Holmes, G. L., Zilberter, Y., Ben-Ari, Y. & Khazipov, R. Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus. Eur. J. Neurosci. 27, 2515–2528 (2008).
35. Minkeviciene, R., Rheims, S., Dobszay, M. B., Zilberter, M., Hartikainen, J., Fülöp, L., Penke, B., Zilberter, Y., Harkany, T., Pitkänen, A. & Tanila, H. Fibrillar β-amyloid-induced hyperexcitability of cortical and hippocampal neurons triggers progressive epilepsy. J. Neurosci. 29, 3453–3462 (2009).
36. Zilberter, M., Holmgren, C., Shemer, I., Silberberg, G., Grillner, S., Harkany, T. & Zilberter, Y. Input specificity and dependence of spike timing-dependent plasticity on preceding postsynaptic activity at unitary connections between neocortical layer 2/3 pyramidal cells. Cereb. Cortex 19, 2308–2320 (2009).
37. Tyzio, R., Khalilov, I., Represa, A., Crepel, V., Zilberter, Y., Rheims, S., Aniksztejn, L., Cossart, R., Nardou, R., Mukhtarov, M., Minlebaev, M., Epsztein, J., Milh, M., Becq, H., Jorquera, I., Bulteau, C., Fohlen, M., Oliver, V., Dulac, O., Dorfmuller, G., Delalande, O., Ben-Ari, Y. & Khazipov, R. Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. Ann. Neurol. 66, 209–218 (2009).
38. Rheims, S., Holmgren, C. D., Chazal, G., Mulder, J., Harkany, T., Zilberter, T. & Zilberter, Y. GABA action in immature neocortical neurons directly depends on the availability of ketone bodies. J. Neurochem. 110, 1330–1338 (2009).
39. Holmgren, C. D., Mukhtarov, M., Malkov, A. E., Popova, I. Y., Bregestovski, P. & Zilberter, Y. Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro. J. Neurochem. 112, 900–912 (2010).
40. Zilberter, Y., Zilberter, T. & Bregestovski, P. Neuronal activity in vitro and the in vivo reality: the role of energy homeostasis. Trends Pharmacol. Sci. 31, 394–401 (2010).
41. Mukhtarov, M., Ivanov, A., Zilberter, Y. & Bregestovski, P. Inhibition of spontaneous network activity in neonatal hippocampal slices by energy substrates is not correlated with intracellular acidification. J. Neurochem. 116, 316–321 (2011).
42. Ivanov, A., Mukhtarov, M., Bregestovski, P. & Zilberter, Y. Lactate effectively covers energy demands during neuronal network activity in neonatal hippocampal slices. Front. Neuroenergetics 3, 1–14 (2011).
43. Ivanov, A. & Zilberter, Y. Critical state of energy metabolism in brain slices: the principal role of oxygen delivery and energy substrates in shaping neuronal activity. Front. Neuroenergetics 3, 9 (2011).
44. Zilberter, Y. & Bregestovski, P. Fueling brain neuronal activity. Biol. Membrany 29, 59–64 (2012).
45. Zilberter, Y. Understanding how the brain ensures its energy supply. Front. Neuroenergetics 4, 9 (2012).
46. Bregestovski, P. & Zilberter, Y. Ion homeostasis, energy substrates, and network activity in developing brain. Biol. Membrany 29, 51–58 (2012).
47. Zilberter, M., Ivanov, A., Ziyatdinova, S., Mukhtarov, M., Malkov, A., Alpar, A., Tortoriello, G., Botting, C. H., Fulop, L., Osypov, A. A., Pitkanen, A., Tanila, H., Harkany, T. & Zilberter, Y. Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer’s disease. J. Neurochem. 125, 157–171 (2013).
48. Zilberter, Y. Energy substrate teamwork and NDD: The major players. Journal of Neurochemistry 125, 97–97 (2013).
49. Silva, C. G., Metin, C., Fazeli, W., Machado, N. J., Darmopil, S., Launay, P. S., Ghestem, A., Nesa, M. P., Bassot, E., Szabo, E., Baqi, Y., Muller, C. E., Tome, A. R., Ivanov, A., Isbrandt, D., Zilberter, Y., Cunha, R. A., Esclapez, M. & Bernard, C. Adenosine receptor antagonists including caffeine alter fetal brain development in mice. Sci. Transl. Med. 5, 197ra104 (2013).
50. Ivanov, A. I., Malkov, A. E., Waseem, T., Mukhtarov, M., Buldakova, S., Gubkina, O., Zilberter, M. & Zilberter, Y. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices. J. Cereb. Blood Flow Metab. 34, 397–407 (2014).
51. Bregestovski, P. & Zilberter, Y. Optogenetics to help exploring the cerebral blood flow regulation. Front. Pharmacol. 5, 107 (2014).
52. Malkov, A., Ivanov, A. I., Popova, I., Mukhtarov, M., Gubkina, O., Waseem, T., Bregestovski, P. & Zilberter, Y. Reactive oxygen species initiate a metabolic collapse in hippocampal slices: potential trigger of cortical spreading depression. J. Cereb. Blood Flow Metab. 34, 1540–1549 (2014).
53. Zilberter, M., Malkov, A., Popova, I., Gubkina, O., Buldakova, S., Tanila, H. & Zilberter, Y. Triple-target treatment for Alzheimer’s: Correcting hypometabolism, oxidative stress, and neuroinflammation. Alzheimers. Dement. 11, P209 (2015).
54. Zilberter, Y., Gubkina, O. & Ivanov, A. I. A unique array of neuroprotective effects of pyruvate in neuropathology. Front. Neurosci. 9, 17 (2015).
55. Zilberter, Y. Commentary: GABA Depolarizes Immature Neurons and Inhibits Network Activity in the Neonatal Neocortex In vivo. Front. Pharmacol. 6, 294 (2015).
56. Koivisto, H., Leinonen, H., Puurula, M., Hafez, H. S., Barrera, G. A., Stridh, M. H., Waagepetersen, H. S., Tiainen, M., Soininen, P., Zilberter, Y. & Tanila, H. Chronic Pyruvate Supplementation Increases Exploratory Activity and Brain Energy Reserves in Young and Middle-Aged Mice. Front. Aging Neurosci. 8, 41 (2016).
57. Popova, I., Malkov, A., Ivanov, A. I., Samokhina, E., Buldakova, S., Gubkina, O., Osypov, A., Muhammadiev, R. S., Zilberter, T., Molchanov, M., Paskevich, S., Zilberter, M. & Zilberter, Y. Metabolic correction by pyruvate halts acquired epilepsy in multiple rodent models. Neurobiol. Dis. 106, 244–254 (2017).
58. Samokhina, E., Popova, I., Malkov, A., Ivanov, A. I., Papadia, D., Osypov, A., Molchanov, M., Paskevich, S., Fisahn, A., Zilberter, M. & Zilberter, Y. Chronic inhibition of brain glycolysis initiates epileptogenesis. J. Neurosci. Res. 95, 2195–2206 (2017).
59. Zilberter, Y. & Zilberter, M. The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction. J. Neurosci. Res. 95, 2217–2235 (2017).
60. Malkov, A., Ivanov, A. I., Buldakova, S., Waseem, T., Popova, I., Zilberter, M. & Zilberter, Y. Seizure-induced reduction in glucose utilization promotes brain hypometabolism during epileptogenesis. Neurobiol. Dis. 116, 28–38 (2018).
61. Zilberter, T. & Zilberter, Y. Ketogenic Ratio Determines Metabolic Effects of Macronutrients and Prevents Interpretive Bias. Front Nutr 5, 75 (2018).
62. Malkov, A., Ivanov, A. I., Latyshkova, A., Bregestovski, P., Zilberter, M. & Zilberter, Y. Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models. Ann. Neurol. 85, 907–920 (2019).